反应详情

To a solution of 1.1 g of dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzyl)aminopyrimidine dissolved in 30 ml of N,N-dimethylformamide was added 0.4 g of cyclopropylmethyl chloride, and the mixture was stirred at 90° to 100° C. for 8 hours. After completion of the reaction, the reaction mixture was charged into water and the separated oily product was extracted with ethyl acetate. The extract was washed with water, dried with anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The oily product obtained was isolated by column chromatography (Wako Gel C-200, trade name, eluted with toluene:ethyl acetate=7:1) to give 0.5 g of the desired product as pale yellow liquid.

1. customAfter completion of the reaction
2. extractionthe separated oily product was extracted with ethyl acetate
3. washThe extract was washed with water
4. dry with materialdried with anhydrous magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure
6. customThe oily product obtained