反应详情

温度

80 °C

To a solution of 5.0 g of dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzyl)aminopyrimidine sodium salt dissolved in 50 ml of N,N-dimethylformamide was added 4.8 g of bromoacetaldehyde diethylacetal, and the mixture was stirred at 80° C. for 8 hours. After completion of the reaction, the reaction mixture was charged into water and the separated oily product was extracted with ethyl acetate. The extract was washed with water, dried with anhydrous sodium sulfate, and then ethyl acetate was distilled off under reduced pressure. The oily product obtained was isolated by column chromatography (Wako Gel C-200, trade name, eluted with toluene:ethyl acetate=7:1) to give 2.3 g of the desired product as pale yellow liquid.

1. customAfter completion of the reaction
2. extractionthe separated oily product was extracted with ethyl acetate
3. washThe extract was washed with water
4. dry with materialdried with anhydrous sodium sulfate
5. distillationethyl acetate was distilled off under reduced pressure
6. customThe oily product obtained