Water → HCID 131716281, compound

HRID 703868Notes

Reaction equation

HRID 703868 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][NH:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][CH2:22][NH2:23])[CH:6]=[CH:5][C:4]=1[OH:24].[Cl:25][C:26]1[N:31]=[C:30]([NH:32][CH:33]([CH:41]([CH3:43])C)[C:34]2[CH:39]=[CH:38][C:37]([OH:40])=[CH:36][CH:35]=2)[CH:29]=[C:28]([CH2:44][CH3:45])[N:27]=1.[Na].Br[CH2:48][CH2:49][O:50][CH2:51][CH2:52]Br.O>CN(C)C=O.C(OCC)(=O)C.C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][NH:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][CH2:22][NH2:23])[CH:6]=[CH:5][C:4]=1[OH:24].[Cl:25][C:26]1[N:31]=[C:30]([NH:32][CH:33]([CH2:41][CH3:43])[C:34]2[CH:35]=[CH:36][C:37]([O:40][CH2:48][CH2:49][O:50][CH2:51][CH3:52])=[CH:38][CH:39]=2)[CH:29]=[C:28]([CH2:44][CH3:45])[N:27]=1

Participants

8

Reactant 4

HCID 962WaterHCID 21521Bis(2-bromoethyl) etherHCID 5360545SodiumHCID 131716283HCID 131716283, compound

Product 1

HCID 131716281HCID 131716281, compoundYield 45.9%

Reagents, catalysts & solvents 3

HCID 1140TolueneSolventHCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 1.2 g of dl-5-chloro-6-ethyl-4-(α-isopropyl-4-hydroxybenzyl)aminopyrimidine. sodium salt dissolved in 30 ml of N,N-dimethylformamide was added 0.6 g of bromoethyl ether, and the mixture was stirred at 80° C. for 8 hours. After completion of the reaction, the reaction mixture was poured into water and the separated oily product was extracted with ethyl acetate. The extract was washed with water, dried with anhydrous sodium sulfate, and then ethyl acetate was distilled off under reduced pressure. The oily product obtained was isolated by column chromatography (Wako Gel C-200, trade name, eluted with toluene:ethyl acetate 32 7:1) to give 0.6 g of the desired product as pale yellow liquid

Workup

  1. customAfter completion of the reaction
  2. extractionthe separated oily product was extracted with ethyl acetate
  3. washThe extract was washed with water
  4. dry with materialdried with anhydrous sodium sulfate
  5. distillationethyl acetate was distilled off under reduced pressure
  6. customThe oily product obtained

Sources & evidence

ORD record
ord-e2a9391d1fc347529f11dcc0c6078b12
Source dataset
uspto-grants-1991_01
Patent number
US04985426

Reaction notes

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