Potassium Carbonate → HCID 13603078, compound

HRID 704950Notes

Reaction equation

HRID 704950 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Cl[CH2:9][C:10]([O:12][CH:13]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:13]([O:12][C:10]([CH2:9][N:5]1[CH:6]=[CH:7][C:2](=[O:1])[CH:3]=[CH:4]1)=[O:11])([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 20077950HCID 20077950, compoundHCID 178418642HCID 178418642, compound

Product 1

HCID 13603078HCID 13603078, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

For instance, 4-hydroxypyridine is reacted with benzhydryl α-chloroacetate in a solvent such as N,N-dimethylformamide in the presence of potassium carbonate at a temperature of from 40° to 80° C. to form 1-benzhydryloxycarbonylmethyl-4-pyridone, followed by a reaction with phosphorus pentasulfide in a solvent such as tetrahydrofuran at a temperature of from 40° to 80° C. to obtain the product of the formula III.

Sources & evidence

ORD record
ord-35c0ab6ae58643688b64504ebbf7c4e1
Source dataset
uspto-grants-1991_01
Patent number
US04988687

Reaction notes

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