反应详情

Boc-Glu-OtBu (75 mg, 0.247 mmol), HATU (112 mg, 0.296 mmol) and HOAt (41 mg, 0.296 mmol) were dissolved in 1 mL of DMF. Triethylamine (52 μL) was added thereto and stirred at room temperature for 10 minutes. 3-Sulfoaniline (43 mg, 0.247 mmol) was added thereto and stirred overnight at room temperature. After removing a solvent, purification was conducted in accordance with the purification process A. The obtained intermediate was dissolved in 2 mL of a trifluoroacetic acid and stirred at room temperature for 3 hours, and a solvent was removed therefrom. The obtained product was purified in accordance with the purification process A to obtain a title compound.

1. stirringstirred overnight at room temperature
2. customAfter removing
3. customa solvent, purification
4. dissolutionThe obtained intermediate was dissolved in 2 mL of a trifluoroacetic acid
5. stirringstirred at room temperature for 3 hours
6. customa solvent was removed
7. customThe obtained product was purified in accordance with the purification process