Ethanol → HCID 49856399, compound

HRID 705504Notes

Reaction equation

HRID 705504 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.O.C([OH:26])CC.C(O)C>C(O)(C)C>[OH2:26].[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

6

Reactant 4

HCID 702EthanolHCID 962WaterHCID 10311-PropanolHCID 248987326-(1H-Imidazol-1-yl)-2-phenylquinazoline

Product 1

HCID 49856399HCID 49856399, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
70 °C

Procedure

50 mg of 6-(1H-imidazol-1-yl)-2-phenylquinazoline are suspended in 4 mL of isopropanol, the suspension is heated at 70° C. for a few minutes, and then filtered and left to evaporate slowly at room temperature, at rest. The crystals obtained are analysed. XRPD: Form B. TGA: weight loss: 6.8% (theoretical value for C17H12N4.H2O: 6.2%), TGA-IR in accordance with the spectrum of H2O for the released vapours. Form B may be obtained analogously from n-propanol and from ethanol.

Workup

  1. filtrationfiltered
  2. waitleft
  3. customto evaporate slowly at room temperature, at rest
  4. customThe crystals obtained

Sources & evidence

ORD record
ord-a7bc8ae1039b41e790b95ac5de2946bb
Source dataset
uspto-grants-2015_11
Patent number
US09174966B2

Reaction notes

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