Benzaldehyde → HCID 178517633, compound

HRID 706268Notes

Reaction equation

HRID 706268 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Si](C#N)(C)(C)C.[N:25]1([C:30](N2C=CN=C2)=[O:31])C=CN=[CH:26]1>>[NH:6]1[C:5]2[CH:9]=[CH:10][C:2]([N:1]3[CH:11]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:26][NH:25][C:30]3=[O:31])=[CH:3][C:4]=2[N:8]=[CH:7]1

Participants

5

Reactant 4

HCID 240BenzaldehydeHCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanide

Product 1

HCID 178517633HCID 178517633, compound

Procedure

The compound was synthesized starting from 5-aminobenzimidazole (1.46 g, 10 mmol), benzaldehyde (1.06 g, 10 mmol), TMSCN (1.25 mL, 10 mmol), PdC (10%, 0.05 g). di-(imidazol-1-yl)methanone (1.73, 12 mmol), as described in method 2.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-03b89f63c15f4cdf95b7b60875a65eab
Source dataset
uspto-grants-2015_11
Patent number
US09173885B2

Reaction notes

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