反应详情

NaH (60% in mineral oil, 1.2 g, 30 mmol) was added to an ice-cooled solution of (4-hydroxy-phenyl)-phenyl-methanone (5 g, 25.2 mmol) in DMF (25 mL). Stirred for 20 minutes at room temperature. Benzyl bromide (6.1 ml, 50 mmol) was added at 0° C. The reaction temperature was raised to room temperature after 1 h. Stirred 2 h. Water (20 mL) was added and aqueous phase was extracted dichloromethane (2×30 mL). The combined organic phase was concentrated and purified by flash chromatography (eluent: dichloromethane). 1H nmr revealed the product was pure. Yield: 7.0 g, 96%

1. temperatureThe reaction temperature was raised to room temperature after 1 h
2. stirringStirred 2 h
3. extractionaqueous phase was extracted dichloromethane (2×30 mL)
4. concentrationThe combined organic phase was concentrated
5. custompurified by flash chromatography (eluent: dichloromethane)