反应详情

To a solution of 5-bromopicolinic acid (25.0 g) and urea. hydrogen peroxide adduct (20.0 g) in acetonitrile (200 mL) was added trifluoroacetic anhydride (50 ml) at 0° C., and the mixture was stirred for 30 min. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The crude crystals were recrystallized from diethyl ether to give the title compound (19.6 g) as white crystals.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe crude crystals were recrystallized from diethyl ether