反应详情

Under a nitrogen atmosphere, to a solution of 5-bromo-2-methyl-4-nitropyridine 1-oxide (4.10 g) in 2-methyl-1-propanol (80 mL) was added 60% sodium hydride (2.69 g) at 0° C., and the mixture was stirred for 2 hr. 6N Hydrochloric acid was added to the reaction mixture, and the resulting brown solid was filtered off. The solvent in the filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (3.40 g) as a pale-yellow solid.

1. filtrationthe resulting brown solid was filtered off
2. customThe solvent in the filtrate was evaporated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate)