反应详情

温度

120 °C

To a solution of ethyl 2-((3-(benzyloxy)phenyl)amino)acetate (1.00 g) in DMF (10 mL) were added potassium carbonate (970 mg) and iodoethane (2.20 g), and the mixture was stirred at 120° C. for 4 hr. The mixture was allowed to cool to room temperature, and water was added. The reaction mixture was extracted with ethyl acetate, and the extract was washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (960 mg) as a colorless oil.

1. temperatureto cool to room temperature
2. extractionThe reaction mixture was extracted with ethyl acetate
3. washthe extract was washed with saturated brine
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. customthe solvent was evaporated under reduced pressure
6. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)