反应详情

To a solution of 5-(3-hydroxy-4-methoxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (556 mg) in THF (10 mL) was added a 1.0 M solution of cyclopropylmagnesium bromide in THF (6.0 mL) at 0° C., and the mixture was stirred for 1 hr. 3N Hydrochloric acid (10 mL) was added to the reaction mixture, and the mixture was stirred for 15 min. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (300 mg) as a yellow solid. This compound was used for the next step without further purification.

1. stirringthe mixture was stirred for 15 min
2. extractionthe mixture was extracted with ethyl acetate
3. washThe extract was washed with saturated brine
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was evaporated under reduced pressure