Hydrochloric Acid → HCID 117839929, compound

HRID 714868Notes

Reaction equation

HRID 714868 reaction equation
[C:1]([C@@:3]1([CH2:32][CH3:33])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[N:17][N:18]([CH:20]4[CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]4)[CH:19]=3)[N:9]=2)[C:4]1=[O:31])#[N:2].[ClH:34]>C(OCC)(=O)C>[ClH:34].[ClH:34].[NH:22]1[CH2:23][CH:20]([N:18]2[CH:19]=[C:15]([NH:14][C:10]3[N:9]=[C:8]([N:5]4[CH2:6][CH2:7][C@:3]([CH2:32][CH3:33])([C:1]#[N:2])[C:4]4=[O:31])[CH:13]=[CH:12][N:11]=3)[CH:16]=[N:17]2)[CH2:21]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117840496HCID 117840496, compound

Product 1

HCID 117839929HCID 117839929, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl 3-(4-((4-((3R)-3-cyano-3-ethyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)azetidine-1-carboxylate (170 mg) obtained in Example 184 was added a solution of 4 M hydrogen chloride in ethyl acetate (6.0 mL), and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure, and the residue was recrystallized (ethanol/ethyl acetate) to give the title compound (120 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized (ethanol/ethyl acetate)

Sources & evidence

ORD record
ord-dc3b23daac38449a9e9265160d532d19
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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