Hydrochloric Acid → HCID 117840655, compound

HRID 714879Notes

Reaction equation

HRID 714879 reaction equation
[C:1]([C@@:3]1([CH2:32][CH3:33])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:27]=[CH:26][C:18]([C:19]([O:21]C(C)(C)C)=[O:20])=[C:17]([O:28][CH2:29][CH3:30])[CH:16]=3)[N:9]=2)[C:4]1=[O:31])#[N:2].[ClH:34]>C(OCC)(=O)C>[ClH:34].[C:1]([C@@:3]1([CH2:32][CH3:33])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:27]=[CH:26][C:18]([C:19]([OH:21])=[O:20])=[C:17]([O:28][CH2:29][CH3:30])[CH:16]=3)[N:9]=2)[C:4]1=[O:31])#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117840452HCID 117840452, compound

Product 1

HCID 117840655HCID 117840655, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl 4-((4-((3R)-3-cyano-3-ethyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)-2-ethoxybenzoate (120 mg) obtained in Step A of Example 250 was added a solution of 4 M hydrogen chloride in ethyl acetate (6.0 mL), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (90 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-f8ca18dc04374b4392775ae138b39199
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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