Hydrochloric Acid → HCID 117840020, compound

HRID 714882Notes

Reaction equation

HRID 714882 reaction equation
[C:1]([C@@:3]1([CH:35]([CH3:37])[CH3:36])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:27]=[CH:26][C:18]([C:19]([O:21]C(C)(C)C)=[O:20])=[C:17]([O:28][CH2:29][C:30]([F:33])([F:32])[F:31])[CH:16]=3)[N:9]=2)[C:4]1=[O:34])#[N:2].[ClH:38]>C(OCC)(=O)C>[ClH:38].[C:1]([C@@:3]1([CH:35]([CH3:37])[CH3:36])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:27]=[CH:26][C:18]([C:19]([OH:21])=[O:20])=[C:17]([O:28][CH2:29][C:30]([F:31])([F:33])[F:32])[CH:16]=3)[N:9]=2)[C:4]1=[O:34])#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117840911HCID 117840911, compound

Product 1

HCID 117840020HCID 117840020, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl 4-((4-((3S)-3-cyano-3-isopropyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)-2-(2,2,2-trifluoroethoxyl)benzoate (120 mg) obtained in Step A of Example 292 was added dropwise a solution of 4 M hydrogen chloride in ethyl acetate (6.0 mL), and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (71 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-2b6f169b00974dfebc91a3e287bd312e
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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