反应详情

温度

85 °C

To a mixture of tert-butyl 3-(3-cyano-2-oxopyrrolidin-3-yl)azetidine-1-carboxylate (1.3 g) obtained in Step C of Example 309, 2,4-dichloropyrimidine (750 mg), cesium carbonate (3.3 g) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (180 mg) in tetrahydrofuran (12 mL) was added tris(dibenzylideneacetone)dipalladium(0) (93 mg), and the mixture was stirred overnight at 85° C. The insoluble substance was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (850 mg)

1. customThe insoluble substance was removed by filtration through Celite
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)