Hydrochloric Acid → HCID 89875345, compound

HRID 715254Notes

Reaction equation

HRID 715254 reaction equation
[F:1][CH:2]([F:27])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH2:11][N:12]2[C:20](=[O:21])[C:19]3[CH:18]=[CH:17][N:16]=[C:15]([NH:22]C(=O)C)[C:14]=3[CH2:13]2)=[CH:7][C:6]=1[CH3:26].[ClH:28]>C1COCC1>[ClH:28].[NH2:22][C:15]1[C:14]2[CH2:13][N:12]([CH2:11][C:8]3[CH:9]=[N:10][C:5]([O:4][CH2:3][CH:2]([F:1])[F:27])=[C:6]([CH3:26])[CH:7]=3)[C:20](=[O:21])[C:19]=2[CH:18]=[CH:17][N:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89875184HCID 89875184, compound

Product 1

HCID 89875345HCID 89875345, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of N-(2-((6-(2,2-difluoroethoxy)-5-methylpyridin-3-yl)methyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)acetamide (200 mg, 0.54 mmol, Step-1) in THF (5.0 mL) is added aqueous hydrochloric acid (3.0 mL) at rt. The reaction mixture is stirred at 90° C. for 16 hours. The reaction mixture is concentrated to give 220 mg (>99% yield) of the title compound as pale yellow solid.

Workup

  1. concentrationThe reaction mixture is concentrated

Sources & evidence

ORD record
ord-0d544df600e14ec898fa011c68205e75
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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