反应详情

The mixed products from 1,1-dimethylethyl (5-chloro-2-pyrazinyl)carbamate were combined and refluxed in 24% sodium ethoxide for 5 days, then cooled to RT, neutralized with HCl, and the product extracted out with DCM. The DCM was washed with saturated NaHCO3, then concentrated to afford a black residue. Addition of EtOAc afforded solids that were filtered off, washed with EtOAc to give ethyl (5-ethoxypyrazin-2-yl)carbamate as a brown solid (3.5 g, 42.9%).

1. extractionthe product extracted out with DCM
2. washThe DCM was washed with saturated NaHCO3
3. concentrationconcentrated
4. customto afford a black residue
5. filtrationwere filtered off
6. washwashed with EtOAc