反应详情

Ethyl 3-acetyl-1H-pyrazole-5-carboxylate (Chem. Commun., 2004, 394-395) (4.82 g) was dissolved in N,N-dimethylformamide (80 ml). To the solution, potassium carbonate (4.39 g) and iodomethane (1.98 ml) were added under ice cooling, and the mixture was stirred at room temperature for 3 hours and 50 minutes. The reaction solution was diluted with ethyl acetate. The organic layer was washed with saturated saline, water, and saturated saline in this order and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane-ethyl acetate) to obtain the title compound (3.38 g).

1. washThe organic layer was washed with saturated saline, water, and saturated saline in this order
2. dry with materialdried over anhydrous sodium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customThe obtained residue was purified by silica gel column chromatography (n-hexane-ethyl acetate)