反应详情

温度

100 °C

Into a 500 mL three-neck flask were put 6.5 g (26 mmol) of 4-bromodiphenylamine, 7.5 g (26 mmol) of 9-phenyl-9H-carbazole-3-boronic acid, and 400 mg (1.3 mmol) of tri(o-tolyl)phosphine. The air in the flask was replaced with nitrogen. To the mixture were added 100 mL of toluene, 50 mL of ethanol, and 14 mL (0.2 mol/L) of an aqueous solution of potassium carbonate. Under reduced pressure, this mixture was degassed while being stirred. After the degassing, 67 mg (30 mmol) of palladium(II) acetate was added to the mixture. This mixture was refluxed at 100° C. for 10 hours. After the reflux, an organic layer of the mixture is separated, an aqueous layer was extracted with toluene, and the extracted solution was combined with the organic layer and then washed with a saturated saline solution. The combined organic layer was dried with magnesium sulfate. After the drying, this mixture was subjected to gravity filtration. The obtained filtrate was condensed to give an oily light brown substance. This oily substance was purified by silica gel column chromatography (a developing solvent was a mixed solvent of hexane:toluene=4:6). A white solid obtained after the purification was recrystallized with a mixed solution of dichloromethane and hexane to give 4.9 g of a white solid, which was the object of the synthesis, in a yield of 45%. A synthesis scheme of Step 2 is shown in (a-2) given below.

1. customInto a 500 mL three-neck flask were put
2. customUnder reduced pressure, this mixture was degassed
3. customAfter the reflux, an organic layer of the mixture is separated
4. extractionan aqueous layer was extracted with toluene
5. washwashed with a saturated saline solution
6. dry with materialThe combined organic layer was dried with magnesium sulfate
7. filtrationAfter the drying, this mixture was subjected to gravity filtration
8. customcondensed
9. customto give an oily light brown substance
10. customThis oily substance was purified by silica gel column chromatography (a developing solvent
11. customA white solid obtained
12. customafter the purification
13. customwas recrystallized with a mixed solution of dichloromethane and hexane