12-Tricosanol → HCID 118516617, compound

HRID 716669Notes

Reaction equation

HRID 716669 reaction equation
[Na].C([O-])(C)C.[Na+:6].[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]([OH:30])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>C(O)(C)C>[CH3:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH:18]([O-:30])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH3:7].[Na+:6]

Participants

5

Reactant 3

HCID 308442912-TricosanolHCID 5360545SodiumHCID 109204432-Propanol, sodium salt (1:1)

Product 1

HCID 118516617HCID 118516617, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Conditions

Temperature
175 °C

Procedure

3.1 g (0.135 mole) sodium metal was dissolved in 40 ml isopropanol under reflux conditions for 4 hrs to make a solution of sodium isopropanolate in isopropanol. 47 g (0.138 mole) 12-tricosanol was added and the resulting isopropanol was subsequently evaporated by heating to 170-180° C. for 2 hrs to yield the sodium 12-tricosanolate for further reaction.

Workup

  1. customthe resulting isopropanol was subsequently evaporated

Sources & evidence

ORD record
ord-5772d3fcb1294c5889405528cee9b9dc
Source dataset
uspto-grants-2015_11
Patent number
US09193653B1

Reaction notes

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