Ammonia → 2-Amino-4,5-dimethoxybenzamide

Temperature

7.5 °C

Into a 1-L 3-necked round-bottom flask, was placed 2-amino-4,5-dimethoxybenzoic acid (20 g, 101.43 mmol, 1.00 equiv), tetrahydrofuran (400 mL), EDC.HCl (39 g, 203.44 mmol, 2.01 equiv) and HOBt (27.5 g, 203.52 mmol, 2.01 equiv). This was followed by the addition of 4-methylmorpholine (20.6 g, 203.96 mmol, 2.01 equiv) dropwise with stirring at 5-10° C. To this was added ammonia (30 mL) dropwise with stirring at 5-10° C. The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum. The resulting solution was diluted with 300 mL of ethyl acetate. The resulting mixture was washed with 1×300 mL of brine. The aqueous layer was extracted with 5×100 mL of ethyl acetate and the organic layers combined. The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 12 g (crude, 61.2% yield) of 2-amino-4,5-dimethoxybenzamide as a yellow solid. MS (ESI) m/z 197 [M+H]+

1. customInto a 1-L 3-necked round-bottom flask, was placed
2. stirringwith stirring at 5-10° C
3. stirringThe resulting solution was stirred overnight at room temperature
4. concentrationThe resulting mixture was concentrated under vacuum
5. additionThe resulting solution was diluted with 300 mL of ethyl acetate
6. washThe resulting mixture was washed with 1×300 mL of brine
7. extractionThe aqueous layer was extracted with 5×100 mL of ethyl acetate
8. dry with materialThe mixture was dried over anhydrous sodium sulfate
9. concentrationconcentrated under vacuum

ORD record

ord-2943726829fc42a498b01e584c2a4d56

Source dataset

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09193707B2