Methylamine → HCID 11121568, compound

HRID 719186Notes

Reaction equation

HRID 719186 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:18]2[C:9](=[N:10][C:11]3[C:16]([N:17]=2)=[C:15]2[CH:19]=[CH:20][CH:21]=[C:22]([O:23][CH3:24])[C:14]2=[CH:13][CH:12]=3)[CH:8]=[CH:7][C:6]=1F)=[O:4].[CH3:26][NH2:27]>O1CCCC1>[CH3:1][O:2][C:3]([C:5]1[C:18]2[C:9](=[N:10][C:11]3[C:16]([N:17]=2)=[C:15]2[CH:19]=[CH:20][CH:21]=[C:22]([O:23][CH3:24])[C:14]2=[CH:13][CH:12]=3)[CH:8]=[CH:7][C:6]=1[NH:27][CH3:26])=[O:4]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 10958632HCID 10958632, compound

Product 1

HCID 11121568HCID 11121568, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 10-fluoro-4-methoxy-benzo[a]phenazine-11-carboxylic acid methyl ester (IV.5) (100 mg) and 2.0M solution of methylamine in tetrahydrofuran was stirred at room temperature for 18 hours. The solvent was then removed in vacuo to yield the crude desired title compound as an orange solid.

Workup

  1. customThe solvent was then removed in vacuo

Sources & evidence

ORD record
ord-0488378b908e477d9c8339afc97ceda9
Source dataset
uspto-grants-2006_11
Patent number
US07132419B2

Reaction notes

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