Potassium Carbonate → HCID 178483815, compound

HRID 719196Notes

Reaction equation

HRID 719196 reaction equation
[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:21]2[C:12](=[N:13][C:14]3[C:19]([N:20]=2)=[C:18]2[CH:22]=[CH:23][CH:24]=[C:25]([C:26]#[N:27])[C:17]2=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=1)=[O:7].C(=O)([O-])[O-].[K+].[K+].Cl.[NH2:36][OH:37]>C(O)C>[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:21]2[C:12](=[N:13][C:14]3[C:19]([N:20]=2)=[C:18]2[CH:22]=[CH:23][CH:24]=[C:25]([C:26](=[NH:27])[NH:36][OH:37])[C:17]2=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=1)=[O:7]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 10270443HCID 10270443, compound

Product 1

HCID 178483815HCID 178483815, compoundYield 91.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-cyano-benzo[a]phenazine-11-carboxylic acid (2-dimethylamino-ethyl)-amide (20 mg), potassium carbonate (37 mg) and hydroxylamine hydrochloride (19 mg) was heated to reflux in ethanol (5 mL) for 18 hours. The reaction mixture was filtered, and the filtrate was collected and the solvent removed in vacuo to yield the title compound (20 mg).

Workup

  1. temperaturewas heated
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was collected
  4. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-00231bde6c0f4fc49447f804ae6ecc38
Source dataset
uspto-grants-2006_11
Patent number
US07132419B2

Reaction notes

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