反应详情

温度

80 °C

2-Chloro-5-iodo-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (5.00 g, Example 14a), tetrabutylammonium chloride (3.40 g) and sodium hydrogencarbonate (2.44 g) were charged to a flask. Pd(OAc)2 (0.0533 g), toluene (50 ml) and allyl alcohol (1.01 ml) were added to afford a pale brown mixture which was heated at 80° C. for 5 h. The resulting dark brown mixture was cooled to ambient then filtered to remove the solid residues. These were washed with further toluene (2×50 ml) and the combined toluene extracts then washed with water (100 ml), dried over MgSO4 and concentrated to a light brown solid (3.82 g).

1. customto afford a pale brown mixture which
2. temperatureThe resulting dark brown mixture was cooled
3. filtrationto ambient then filtered
4. customto remove the solid residues
5. washThese were washed with further toluene (2×50 ml)
6. washthe combined toluene extracts then washed with water (100 ml)
7. dry with materialdried over MgSO4
8. concentrationconcentrated to a light brown solid (3.82 g)