Sodium Bicarbonate → HCID 135828224, compound

HRID 720452Notes

Reaction equation

HRID 720452 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([SH:19])[N:3]=1.Br.Br[CH2:22][CH2:23][NH2:24].C([O-])(O)=O.[Na+]>CN(C=O)C.Cl>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:22][CH2:23][NH2:24])[N:3]=1

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 27742172-Bromoethylamine hydrobromideHCID 178510481HCID 178510481, compound

Product 1

HCID 135828224HCID 135828224, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 6228DimethylformamideSolvent

Procedure

268 mg (1 mmol) of 2-amino-4-(4-hydroxyphenyl)-6-sulfanyl-3,5-pyridinedicarbonitrile, 105 mg (1 mmol) of 2-bromoethylamine hydrobromide and 168 mg (2 mmol) of NaHCO3 are stirred in 1 ml of DMF for 1 hour. The entire mixture is diluted with a few milliliters of 1N HCl. The crystals are filtered off with suction and dried under reduced pressure.

Workup

  1. filtrationThe crystals are filtered off with suction
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-2342196d5d1f465ba0c3943b3caf9250
Source dataset
uspto-grants-2006_11
Patent number
US07135486B1

Reaction notes

Loading…