反应详情

Compound 25 (0.60 g, 1 mmol) and compound 26 (0.46 g, 1 mmol) were dissolved in 10 ml DMF and HBTU (0.7 g, 1.8 mmol) was added as a solid followed by DIEA (1.0 ml, 5.7 mmol). The reaction mixture was stirred at room temperature overnight, diluted with EtOAc and the organic phase washed with 0.5N NaOH, brine, dried over MgSO4, filtered and concentrated to an oil. This oil was purified by flash silica chromatography (10 to 20% MeOH/EtOAc) to give a yellow foam (0.65 g, 0.62 mmol, 62%, compound 28).

1. washthe organic phase washed with 0.5N NaOH, brine
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated to an oil
5. customThis oil was purified by flash silica chromatography (10 to 20% MeOH/EtOAc)