反应详情

A vigorously stirred mixture of 2-aminoadamantane hydrochloride (5.01 g, 26.7 mmol), CH2Cl2 (50 mL) and satd aq NaHCO3 (50 mL) was cooled in an ice bath. After 15 min, solid triphosgene (2.64 g, 8.9 mmol) was added. The mixture was stirred in the ice bath for 30 min and the layers were separated. The aqueous layer was extracted with CH2Cl2 (100 mL). The combined organic layers were washed with brine (50 mL), dried over MgSO4 and concentrated under reduced pressure to afford the title compound (3.55 g, 75%) as a white solid.

1. temperaturewas cooled in an ice bath
2. customthe layers were separated
3. extractionThe aqueous layer was extracted with CH2Cl2 (100 mL)
4. washThe combined organic layers were washed with brine (50 mL)
5. dry with materialdried over MgSO4
6. concentrationconcentrated under reduced pressure