Triphosgene → HCID 21889945, compound

HRID 721377Notes

Reaction equation

HRID 721377 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1.Cl[C:24](Cl)([O:26]C(=O)OC(Cl)(Cl)Cl)Cl.[O:35]1[CH2:40][CH2:39][N:38]([CH2:41][CH2:42][CH:43]([OH:47])[CH2:44][CH2:45][CH3:46])[CH2:37][CH2:36]1.C(=O)(O)[O-].[Na+]>C(Cl)Cl.C(N(CC)CC)C.C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH:20][C:24](=[O:26])[O:47][CH:43]([CH2:42][CH2:41][N:38]2[CH2:39][CH2:40][O:35][CH2:36][CH2:37]2)[CH2:44][CH2:45][CH3:46])=[CH:18][CH:17]=1

Participants

8

Reactant 4

HCID 94429TriphosgeneHCID 516892Sodium BicarbonateHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]anilineHCID 21890612HCID 21890612, compound

Product 1

HCID 21889945HCID 21889945, compoundYield 93%

Reagents, catalysts & solvents 3

HCID 1140TolueneSolventHCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (50 mg) was added to toluene. (5 ml), and triethylamine (0.5 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (77 mg) in methylene chloride was then added thereto, and the mixture was heated under reflux for 10 min. Next, 1-morpholino-3-hexanol (49 mg) was added thereto, and the mixture was further stirred with heating under reflux for 3 hr. A saturated aqueous sodium bicarbonate solution was added to stop the reaction, and the reaction solution was then extracted with chloroform, and the extract was washed with water and saturated brine in that order. The extract was dried over sodium sulfate and was then concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (80 mg, yield 81%).

Workup

  1. temperatureunder reflux
  2. customto prepare a solution
  3. temperaturethe mixture was heated
  4. temperatureunder reflux for 10 min
  5. temperaturewith heating
  6. temperatureunder reflux for 3 hr
  7. customthe reaction
  8. extractionthe reaction solution was then extracted with chloroform
  9. washthe extract was washed with water and saturated brine in that order
  10. dry with materialThe extract was dried over sodium sulfate
  11. concentrationwas then concentrated
  12. customThe residue was purified on a column

Sources & evidence

ORD record
ord-c22ae385363d4d0282d02b0cb9a552d4
Source dataset
uspto-grants-2006_11
Patent number
US07135466B2

Reaction notes

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