Guanidine Hydrochloride → HCID 15407136, compound

HRID 721993Notes

Reaction equation

HRID 721993 reaction equation
[H-].[Na+].[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)#[N:4].Cl.[NH2:12][C:13]([NH2:15])=[NH:14]>CS(C)=O>[N:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3]1[N:4]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=2)[N:12]=[C:13]([NH2:15])[N:14]=1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 7522Pyridine-2-carbonitrileHCID 24758Sodium hydride

Product 1

HCID 15407136HCID 15407136, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1.0 g (approximately 60% dispersion in paraffin oil, about 25 mmol) of sodium hydride is added in portions to a mixture of 5.21 g (50 mmol) of 2-cyanopyridine and 2.39 g (25 mmol) of guanidine hydrochloride in 100 ml of dimethyl sulfoxide. Stirring is carried out for 2 hours at room temperature, and then for 23 hours at 75° C. The mixture is cooled and poured into 100 ml of ice-water and filtered, yielding 4,6-di-pyrid-2-yl-[1,3,5]triazin-2-ylamine in the form of a white solid after drying in vacuo.

Workup

  1. waitfor 23 hours at 75° C
  2. temperatureThe mixture is cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-3218862c9e8c415db51c20471aa4ab8f
Source dataset
uspto-grants-2006_11
Patent number
US07138363B2

Reaction notes

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