反应详情

The solution of 2.67 g of 1-(4-fluoro-2-nitrophenyl)piperidine-3-carboxamide in 100 ml of THF was admixed with 260 mg of Pd/C. This mixture was hydrogenated in a shaking vessel at atmospheric pressure until the theoretical amount of hydrogen had been taken up. The mixture is then acidified with hydrogen chloride dissolved in ethyl acetate, the solid is filtered off with suction and washed with methanol, and the filtrate is concentrated under reduced pressure. The residue is triturated with tert-butyl methyl ether and the solid is filtered off with suction and dried under reduced pressure.

1. filtrationthe solid is filtered off with suction
2. washwashed with methanol
3. concentrationthe filtrate is concentrated under reduced pressure
4. customThe residue is triturated with tert-butyl methyl ether
5. filtrationthe solid is filtered off with suction
6. customdried under reduced pressure