Oxalyl chloride → 4-Methoxy-3-nitrobenzoyl chloride

HRID 722491Notes

Reaction equation

HRID 722491 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH3:7][O:8][C:9]1[CH:17]=[CH:16]C(C(O)=O)=[CH:11][C:10]=1[N+:18]([O-:20])=[O:19]>C1COCC1>[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:1]([C:2]([Cl:4])=[O:3])=[CH:11][C:10]=1[N+:18]([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 666404-Methoxy-3-nitrobenzoic acid

Product 1

HCID 123754634-Methoxy-3-nitrobenzoyl chloride

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Oxalyl chloride (15.8 ml, 180 mmol) was added dropwise with stirring to a solution of 4-methoxy-3-nitrobenzoic acid (7.00 g, 36.00 mmol) in THF containing 10 μL DMF. After 1 h the solvent was removed under reduced pressure. The product was used directly in the next step.

Workup

  1. customAfter 1 h the solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-78d80d48ad5e4408834a0a40c6d6770a
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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