反应详情

A solution of 1-[4-(2-bromoethoxy)phenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one (50 mg) in acetonitrile (1 ml) was mixed with phenethylamine (47 mg), potassium carbonate (70 mg) and sodium iodide (5 mg) and boiled under reflux for 2 hours. The cooled solution was filtered and concentrated. The residue was purified by preparative HPLC. The product with the molecular weight of 491.60 (C31 H29N3O3); MS (ESI): 492 ([M+H]+), was obtained as hydroformate in this way.

1. temperatureunder reflux for 2 hours
2. filtrationThe cooled solution was filtered
3. concentrationconcentrated
4. customThe residue was purified by preparative HPLC
5. customMS (ESI): 492 ([M+H]+), was obtained as hydroformate in this way