反应详情

温度

60 °C

1,1′-Carbonyldiimidazole (11.4 g, 0.0703 mol) is added portionwise to a solution of 2-amino-3-fluorophenol (Step 3, 8.94 g, 0.0703 mol) in THF (200 ml) and warmed at 60° C. for 2 h. The reaction mixture is diluted with ethyl acetate (200 ml), washed with 2N HCl and saline, dried (MgSO4), and evaporated to give product as a white solid suitable for use in the next step (10.6 g, 99%); mp 131–3° C.

1. washwashed with 2N HCl and saline
2. dry with materialdried (MgSO4)
3. customevaporated
4. customto give product as a white solid suitable for use in the next step (10.6 g, 99%)