Iodoethane → HCID 45095618, compound

HRID 723929Notes

Reaction equation

HRID 723929 reaction equation
I[CH2:2][CH3:3].[F:4][C:5]1[C:10]2[NH:11][C:12](=[O:14])[O:13][C:9]=2[CH:8]=[C:7]([N+:15]([O-:17])=[O:16])[CH:6]=1.N12CCCN=C1CCCCC2>CN(C=O)C>[CH2:2]([N:11]1[C:10]2[C:5]([F:4])=[CH:6][C:7]([N+:15]([O-:17])=[O:16])=[CH:8][C:9]=2[O:13][C:12]1=[O:14])[CH3:3]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 684892924-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one

Product 1

HCID 45095618HCID 45095618, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared from iodoethane (0.61 ml, 7.57 mmol), 4-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one (EXAMPLE 86, Step 5, 1.2 g, 6.06 mmol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (1.13 ml, 7.57 mmol) in DMF (10 ml) according to the method of EXAMPLE 86, Step 6 (1.10 g, 80%); mp 121–2° C.

Sources & evidence

ORD record
ord-940ca23f6a2f4a42ad612009ac22557b
Source dataset
uspto-grants-2006_11
Patent number
US07141588B2

Reaction notes

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