Oxalyl chloride → 4301-04-6

HRID 724787Notes

Reaction equation

HRID 724787 reaction equation
[Cl:1][CH2:2][C:3]([CH2:8][Cl:9])([CH3:7])[C:4](O)=[O:5].C(Cl)(=O)C([Cl:13])=O>CN(C=O)C.C(Cl)Cl>[Cl:1][CH2:2][C:3]([CH2:8][Cl:9])([CH3:7])[C:4]([Cl:13])=[O:5]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 105411Propanoic acid, 3-chloro-2-(chloromethyl)-2-methyl-

Product 1

HCID 43210274301-04-6

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

DMF (1 drop) was added to a solution of 2,2-bis(chloromethyl)propanoic acid (1.4 g) in DCM (1.5 ml), the solution was cooled to 0° C. and oxalyl chloride (0.75 ml) added. After gas evolution had stopped the mixture was concentrated in vacuo to give the sub-title compound as a yellow oil (1.51 g) which was used directly in the next step.

Workup

  1. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-51088c7e1b4740c4b2634ad1b954d56c
Source dataset
uspto-grants-1998_01
Patent number
US05705456

Reaction notes

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