反应详情

温度

50 °C

To a stirred solution of 6-bromo-1,2,3,4-tetrahydro-quinoline (3.00 g, 12.1 mmol) in dimethylformamide (25 mL) was added potassium carbonate (3.3 g, 24.1 mmol), sodium iodide (0.905 g, 6.0 mmol) and 4-methoxybenzyl chloride (2.5 mL, 18.1 mmol) and heated at 50° C. After 18 h, reaction mixture was cooled to room temperature and quenched by the addition of water and extracted with ethyl acetate (2×20 mL). The organic layer was washed with water (2×20 mL), brine (20 mL), dried over sodium sulfate, concentrated and purified by the silica gel column chromatography to furnish 6-bromo-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-quinoline (2.5 g).

1. customreaction mixture
2. temperaturewas cooled to room temperature
3. customquenched by the addition of water
4. extractionextracted with ethyl acetate (2×20 mL)
5. washThe organic layer was washed with water (2×20 mL), brine (20 mL)
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated
8. custompurified by the silica gel column chromatography