Methyl iodide → HCID 19710186, compound

HRID 725929Notes

Reaction equation

HRID 725929 reaction equation
[F:1][C:2]([F:25])([F:24])[S:3]([O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[OH:16])[CH2:12][CH:11]([N:17]([CH2:21][CH2:22][CH3:23])[CH2:18][CH2:19][CH3:20])[CH2:10]2)(=[O:5])=[O:4].[H-].[Na+].[CH3:28]I>CN(C=O)C>[F:25][C:2]([F:24])([F:1])[S:3]([O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[O:16][CH3:28])[CH2:12][CH:11]([N:17]([CH2:21][CH2:22][CH3:23])[CH2:18][CH2:19][CH3:20])[CH2:10]2)(=[O:4])=[O:5]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 18705875HCID 18705875, compound

Product 1

HCID 19710186HCID 19710186, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

A solution of 5-trifluoromethansulfonyloxy-6-hydroxy-2-(di-n-propylamino)indan (Example 7) in DMF is added to a suspension of sodium hydride in DMF under nitrogen. The mixture is alkylated with methyl iodide to yield the title compound.

Sources & evidence

ORD record
ord-0f6a4f144cc54f129964afc57bd9220b
Source dataset
uspto-grants-1998_01
Patent number
US05708018

Reaction notes

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