Diisobutylaluminum hydride → HCID 19710200, compound

HRID 725930Notes

Reaction equation

HRID 725930 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH:9]([N:16]([CH2:20][CH2:21][CH3:22])[CH2:17][CH2:18][CH3:19])[CH2:8]2)(OC)=[O:2].CC(C[AlH]CC(C)C)C>C1COCC1>[CH:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH:9]([N:16]([CH2:17][CH2:18][CH3:19])[CH2:20][CH2:21][CH3:22])[CH2:8]2)=[O:2]

Participants

4

Reactant 2

HCID 14487Diisobutylaluminum hydrideHCID 19710195HCID 19710195, compound

Product 1

HCID 19710200HCID 19710200, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 5-carbomethoxy-6-methoxy-2-(di-n-propylamino)indan (Example 57) in THF under nitrogen is treated with DIBAL-H at -78° C. After work-up and purification, the title compound is obtained.

Workup

  1. customAfter work-up and purification

Sources & evidence

ORD record
ord-e6d3e01ac1ee4ba3bd2460859a17f53e
Source dataset
uspto-grants-1998_01
Patent number
US05708018

Reaction notes

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