Hydrochloric Acid → HCID 86751950, compound

HRID 726431Notes

Reaction equation

HRID 726431 reaction equation
[NH2:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1.[C:17]1(=[O:23])O[C:20](=[O:21])[CH2:19][CH2:18]1.C([N:26](CC)CC)C.Cl>ClCCl>[C:13]([O:12][C:10]([N:7]1[CH2:6][CH2:5][CH:4]([CH2:3][CH2:2][NH:1][C:17](=[O:23])[CH2:18][CH2:19][C:20]([NH2:26])=[O:21])[CH2:9][CH2:8]1)=[O:11])([CH3:16])([CH3:15])[CH3:14]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7922Succinic anhydrideHCID 8471TriethylamineHCID 1514258tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate

Product 1

HCID 86751950HCID 86751950, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (100 mg) obtained in the above (5) is dissolved in dichloromethane (2 ml), and thereto are added succinic anhydride (53 mg) and triethylamine (73 μl), and the mixture is stirred at room temperature for 45 minutes. To the mixture is added 1N hydrochloric acid, and the mixture is extracted three time with ethyl acetate. The extract is washed twice with a saturated brine, and the organic layer is dried over anhydrous magnesium sulfate. The desiccant is removed by filtration, and the filtrate is concentrated under reduced pressure to give the title compound (139 mg).

Workup

  1. extractionthe mixture is extracted three time with ethyl acetate
  2. washThe extract is washed twice with a saturated brine
  3. dry with materialthe organic layer is dried over anhydrous magnesium sulfate
  4. customThe desiccant is removed by filtration
  5. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-2c648a4ced824eaa9ba7c94b8a016e93
Source dataset
uspto-grants-1998_01
Patent number
US05707994

Reaction notes

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