反应详情

3-Fluoro-4-nitrobenzoic acid 5.55 g, 2-ethoxyethylamine 3.15 mL, N,N-diisopropylethylamine 5.23 mL, 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride 8.63 g, 1-hydroxybenzotriazole monohydrate 5.96 g and acetonitrile 77 mL were mixed and stirred for 19 hours. The reaction liquid was poured in diluted hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine, saturated aqueous sodium hydrogencarbonate solution and saturated brine, by the order stated, and dried over magnesium sulfate. Distilling the solvent off, 6.86 g of the title compound was obtained.

1. customThe reaction liquid
2. extractionextracted with ethyl acetate
3. washThe extract was washed with saturated brine, saturated aqueous sodium hydrogencarbonate solution and saturated brine, by the order
4. dry with materialdried over magnesium sulfate
5. distillationDistilling the solvent off, 6.86 g of the title compound
6. customwas obtained