反应详情

3-Fluoro-4-nitrobenzoic acid 2.78 g, 3-pyridylmethylamine 1.55 mL, N,N-diisopropylethylamine 2.61 mL, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 4.31 g, 1-hydroxybenzotriazole monohydrate 2.98 g and acetonitrile 39 mL were mixed and stirred for 20 hours. The reaction liquid was poured in saturated aqueous sodium hydrogencarbonate solution and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine by the order stated, and dried over magnesium sulfate. Distilling the solvent off, 4.09 g of the title compound was obtained.

1. customThe reaction liquid
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine by the order
4. dry with materialdried over magnesium sulfate
5. distillationDistilling the solvent off, 4.09 g of the title compound
6. customwas obtained