Potassium Carbonate → HCID 178444531, compound

HRID 727762Notes

Reaction equation

HRID 727762 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1O)=[O:4].[CH2:14]([C@H:19]1[CH2:24][CH2:23][C@H:22]([CH2:25]Br)[CH2:21][CH2:20]1)[CH2:15][CH2:16][CH2:17][CH3:18].C([O-])([O-])=[O:28].[K+].[K+]>CN(C=O)C>[CH2:14]([C@H:19]1[CH2:24][CH2:23][C@H:22]([CH2:25][O:28][C:8]2[CH:9]=[CH:10][C:5]([C:3](=[O:4])[C:2]([F:13])([F:12])[F:1])=[CH:6][CH:7]=2)[CH2:21][CH2:20]1)[CH2:15][CH2:16][CH2:17][CH3:18]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27611642-TrifluoroacetylphenolHCID 178444389HCID 178444389, compound

Product 1

HCID 178444531HCID 178444531, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 0.1 mol of trifluoroacetylphenol, 0.11 mol of trans-4-pentylcyclohexylmethyl bromide, 0.3 mol of K2CO3 and 250 ml DMF is heated at 140° C. for 10 hours. Customary work-up and crystallization give 4-(trans-4-pentylcyclohexylmethoxy)-1-trifluoroacetylbenzene, mp. 60° C., Δε=13.7.

Workup

  1. customCustomary work-up and crystallization

Sources & evidence

ORD record
ord-657f9c54baf848608026045d8a1307ff
Source dataset
uspto-grants-1991_09
Patent number
US05045229

Reaction notes

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