反应详情

In 30 ml of benzene was dissolved 2.3 g of 4-bromomethylbenzoic acid chloride, 1.37 g of n-octyl alcohol and 5 ml of triethylamine were added to the solution, and a reaction was carried out at room temperature with stirring overnight. Then, 30 ml of ethyl acetate and 10 ml of 2N HCl were added to the reaction mixture, and the organic layer was separated, washed with water and dried on magnesium sulfate. The solvent was removed by distillation, and the residue was separated and purified by the silica gel column chromatography to obtain 3.0 g of octyl 4-bromomethylbenzoate.

1. additionwere added to the solution
2. customwas carried out at room temperature
3. customthe organic layer was separated
4. washwashed with water
5. customdried on magnesium sulfate
6. customThe solvent was removed by distillation
7. customthe residue was separated
8. custompurified by the silica gel column chromatography