反应详情

A solution of 3-dibenzylamino-6,7-difluoro-1H-quinazoline-2,4-dione (Example 16) (0.43 g, 1.1 mmol) in 10 mL of N,N-dimethylformamide is added to a suspension of sodium hydride (0.05 g, 1.3 mmol) in 10 mL of N,N-dimethylformamide and stirred for 30 minutes. Bromomethylcyclopropane (0.16 mL, 1.6 mmol) is added, and the mixture is stirred at 25° C. for 18 hours. The reaction is quenched with 1 mL of water and concentrated in vacuo. The residue is dissolved in chloroform, washed with water, brine, and dried over magnesium sulfate. The solution is concentrated and purified via chromatography (SiO2, CHCl3) to give 0.33 g of the title compound as a solid. MS CI: m/z 448 (MH+).

1. stirringthe mixture is stirred at 25° C. for 18 hours
2. customThe reaction is quenched with 1 mL of water
3. concentrationconcentrated in vacuo
4. dissolutionThe residue is dissolved in chloroform
5. washwashed with water, brine
6. dry with materialdried over magnesium sulfate
7. concentrationThe solution is concentrated
8. custompurified via chromatography (SiO2, CHCl3)