Pyrrolidine → Pyrrolidine-1-sulfonamide

HRID 729677Notes

Reaction equation

HRID 729677 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[S:6](N)([NH2:9])(=[O:8])=[O:7]>O1CCOCC1>[N:1]1([S:6]([NH2:9])(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 82267Sulfamide

Product 1

HCID 15707376Pyrrolidine-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Pyrrolidine (3.37 g) and sulfamide (7.10 g) in 1,4-dioxane (110 ml) were heated at reflux for 24 h. The solvent was evaporated under reduced pressure and the resulting solid suspended in CHCl3. The suspension was filtered and the filtrate concentrated in vacuo to afford the subtitle compound as a white solid. Yield: 5.35 g.

Workup

  1. temperatureat reflux for 24 h
  2. customThe solvent was evaporated under reduced pressure
  3. filtrationThe suspension was filtered
  4. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-7ead16268e084453b8f6d56e5118e8fb
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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