Ethylamine hydrochloride → HCID 21094217, compound

HRID 729738Notes

Reaction equation

HRID 729738 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH:8]([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=O)=[CH:19][CH:18]=2)[C:9](=[O:16])[NH:10][C:11]2[S:12][CH:13]=[CH:14][N:15]=2)[CH2:3][CH2:2]1.[CH2:26]([NH2:28])[CH3:27].Cl.CCN(C(C)C)C(C)C>>[CH2:26]([NH:28][C:21](=[O:23])[C:20]1[CH:24]=[CH:25][C:17]([CH:8]([C:9](=[O:16])[NH:10][C:11]2[S:12][CH:13]=[CH:14][N:15]=2)[CH2:7][CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[CH:18][CH:19]=1)[CH3:27]

Participants

4

Reactant 3

HCID 11198Ethylamine hydrochlorideHCID 81531DiisopropylethylamineHCID 21094067HCID 21094067, compound

Product 1

HCID 21094217HCID 21094217, compound

Procedure

4-[2-(Tetrahydropyran-4-yl)-1-(thiazol-2-ylcarbamoyl)ethyl]benzoic acid (Preparation 62, 150 mg, 420 μmol) was condensed with EtNH2.HCl in the presence of DIPEA, utilising the general procedure described in EXAMPLE 65, to give the title compound: RTA=2.97 min; m/z (ES+)=388.3 [M+H]+.

Sources & evidence

ORD record
ord-ea73163662ee44f2b3feb35db9cfaaff
Source dataset
uspto-grants-2009_09
Patent number
US07582632B2

Reaction notes

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