Potassium Carbonate → HCID 68817478, compound

HRID 731086Notes

Reaction equation

HRID 731086 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=3)[CH:7]=[CH:8][CH:9]=2)[C:4]([CH3:18])=[C:3]1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:32][C:33]([O:35][CH3:36])=[O:34]>CC(C)=O>[CH3:36][O:35][C:33](=[O:34])[CH2:32][O:17][C:14]1[CH:15]=[CH:16][C:11]([C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[C:4]([CH3:18])=[C:3]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:2]3[CH3:1])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 68813887HCID 68813887, compound

Product 1

HCID 68817478HCID 68817478, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The desired product was prepared using a procedure similar to step 1 of example 4. Thus, 4-(1,3-dimethyl-2-phenyl-1H-indol-4-yl)-phenol (0.300 g, 0.957 mmol) was reacted with K2CO3 (0.172 g, 1.244 mmol) and methyl bromoacetate (0.190 g, 1.244 mmol) in acetone (5 ml) to give the product (0.287 g, 0.745 mmol, 78%) as a white solid, mp 110-112° C.

Sources & evidence

ORD record
ord-5f0d4149138b4aa6aa7fd66e5af0d663
Source dataset
uspto-grants-2009_09
Patent number
US07582773B2

Reaction notes

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