Hydrochloric Acid → HCID 178526035, compound

HRID 731467Notes

Reaction equation

HRID 731467 reaction equation
C([O:3][C:4](=[O:36])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[C@H:16]2[CH2:21][CH2:20][C@H:19]([CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.[OH-].[Na+].Cl>O1CCCC1>[CH:30]1([N:15]([C@H:16]2[CH2:21][CH2:20][C@H:19]([CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:18][CH2:17]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:36])=[O:3])=[CH:8][N:9]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178473155HCID 178473155, compound

Product 1

HCID 178526035HCID 178526035, compoundYield 96.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

80 mg of {2-[3-cyclohexyl-3-(trans-4-phenoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester was dissolved in tetrahydrofuran (1 mL) and 1N sodium hydroxide (1 mL) was added. Stirred at room temperature for 2 h then acidified with 1N hydrochloric acid. White precipitate filtered and dried to give the title compound (73 mg)

Workup

  1. customWhite precipitate
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-ac15c23c5bf54fbb8d904eea2355661a
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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