2-Bromopropane → 3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

HRID 731772Notes

Reaction equation

HRID 731772 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[N:8][C:9]=2[NH2:11])[NH:4][N:3]=1.C([O-])([O-])=O.[K+].[K+].[CH:18](Br)([CH3:20])[CH3:19]>CN(C=O)C>[I:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[N:8][C:9]=2[NH2:11])[N:4]([CH:18]([CH3:20])[CH3:19])[N:3]=1

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 178508725HCID 178508725, compound

Product 1

HCID 249053373-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineYield 72%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2 g, 0.0077 mol) and K2CO3 (4.2 g, 0.031 mol) in DMF (50 mL) was brought to 80° C. under an argon atmosphere. Isopropylbromide (1.0 g, 0.0084 mol) was added with a syringe. Reaction was refluxed under argon atmosphere for 2 hours. Solid K2CO3 was removed by filtration. Solvent was partially removed in vacuo. Sodium citrate (50 mL) was added and reaction was extracted with EtOAc. Organic phases concentrated in vacuo and purified using silica gel column chromatography [MeOH—CH2Cl2, 5:95] yielding BA12 (1.68 g, 72% yield). ESI-MS (M+H)+ m/z calcd 304.0, found 304.1.

Workup

  1. customwas brought to 80° C. under an argon atmosphere
  2. customReaction
  3. temperaturewas refluxed under argon atmosphere for 2 hours
  4. customSolid K2CO3 was removed by filtration
  5. customSolvent was partially removed in vacuo
  6. additionSodium citrate (50 mL) was added
  7. customreaction
  8. extractionwas extracted with EtOAc
  9. concentrationOrganic phases concentrated in vacuo
  10. custompurified

Sources & evidence

ORD record
ord-574af9f4b7a14158bb406364d92eb9f0
Source dataset
uspto-grants-2009_09
Patent number
US07585868B2

Reaction notes

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